"Motor Protein 'Hook' Unveils Neuron Cargo Delivery Mechanisms"

A groundbreaking study reveals the atomic structure of the Motor protein kinesin-2, enhancing understanding of how it delivers cargo in neurons, crucial for cellular function.

• Led by Professor Nobutaka Hirokawa from Juntendo University, the research elucidates the interaction between Motor protein kinesin-2s tail and Signal transducing adaptor protein for cargo binding.
• Utilizing Cryogenic electron microscopy, the study detailed the Protein structure of kinesin-2, identifying a unique Structural motif that facilitates its function in neuron cargo transport.
• Collaborators included Dr. Masahide Kikkawa from the University of Tokyo, indicating a significant academic partnership in advancing cellular biology and understanding of Adenomatous polyposis coli in neuronal contexts.